After a series of recent restoration projects throughout the city, Rome is officially refreshed and ready for its close-up. When you visit Italy's capital city, prepare to cross a few must-see landmarks – including the Colosseum, the Trevi Fountain and the Pantheon – off of your bucket list. Travelers can also see some of Italy's greatest treasures, including St. Peter's Basilica, the Sistine Chapel and a new pope in Vatican City. Once you get your bearings, peruse some of Rome's lesser-known museums, art galleries and boutiques, or head to Janiculum Hill for panoramic views of the city.

Simply setting foot in Japan's frenetic capital city is an experience. Known for its bustling streets and flashing neon signs, Tokyo has an electric energy and ample top attractions to discover. Foodies won't be disappointed by Tokyo's fresh sushi and hearty ramen (not to mention more Michelin-starred restaurants than any other city in the world). Shopaholics will find plenty of must-have designer products in Ginza, while those seeking a respite in nature can visit Shinjuku Gyoen or Yoyogi Park. Meanwhile, history buffs will appreciate Tokyo's centuries-old temples and shrines.

Prague's Gothic sites make for a moody backdrop to your European vacation. From the flying buttresses of St. Vitus Cathedral to the statue-studded Old Town Bridge tower, those with an appreciation for architecture will find plenty to marvel at in Czechia's capital city. Aside from touring these and other top attractions, you'll want to leave some gaps in your itinerary to saunter along the Náplavka (an embankment on the Vltava River) and sample Czech specialties – best paired with a Pilsner.